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Bioavailability of Reservatrol with Piperine

Type: Literature (pdf)

Submitter: [anonymous]

Submission Date: 2016-06-11 02:56:53 MST

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Submitter's Comment
Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation

Emma L. Wightman1*, Jonathon L. Reay2, Crystal F. Haskell1, Gary Williamson3, Tristan P. Dew3 and David O. Kennedy1 1Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne NE1 8ST, UK 2School of Social Sciences and Law, Teesside University, Middlesbrough TS1 3BA, UK 3School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT, UK
(Submitted 26 April 2013 – Final revision received 23 December 2013 – Accepted 23 January 2014 – First published online 7 May 2014)

Abstract
Previous research has shown that resveratrol can increase cerebral blood flow (CBF) in the absence of improved cognitive performance in healthy, young human subjects during the performance of cognitively demanding tasks. This lack of cognitive effects may be due to low bioavailability and, in turn, reduced bioefficacy of resveratrol in vivo. Piperine can alter polyphenol pharmacokinetics, but previous studies have not investigated whether this affects the efficacy of the target compound. Therefore, the objective of the present study was to ascertain whether co-supplementation of piperine with resveratrol affects the bioavailability and efficacy of resveratrol with regard to cognition and CBF. The present study utilised a randomised, double-blind, placebo-controlled, within-subjects design, where twenty-three adults were given placebo, trans-resveratrol (250mg) and trans-resveratrol with 20mg piperine on separate days at least a week apart. After a 40min rest/absorption period, the participants performed a selection of cognitive tasks and CBF was assessed throughout the period, in the frontal cortex, using near-IR spectroscopy. The presence of resveratrol and its conjugates in the plasma was confirmed by liquid chromatography–MS analysis carried out following the administration of the same doses in a separate cohort (n 6). The results indicated that when co-supplemented, piperine and resveratrol significantly augmented CBF during task performance in comparison with placebo and resveratrol alone. Cognitive function, mood and blood pressure were not affected. The plasma concentrations of resveratrol and its metabolites were not significantly different between the treatments, which indicates that co-supplementation of piperine with resveratrol enhances the bioefficacy of resveratrol with regard to CBF effects, but not cognitive performance, and does this without altering bioavailability.
Key words:

Keywords: Resveratrol Piperine Near-IR spectroscopy Cognitive performance Cerebral blood flow Bioavalbilitity

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