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Unifiram and Sunifiram, New Potent Nootropics

Type: Literature (pdf)

Submitter: Limitless

Submission Date: 2015-04-12 07:26:17 MST

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Submitter's Comment
Pharmacological Characterization of DM232
(Unifiram) and DM235 (Sunifiram),
New Potent Cognition Enhancers
M. N. Romanellia
, N. Galeottib, C. Ghelardinib,
D. Manettia
, E. Martinia
, F. Gualtieria
aDipartimento di Scienze Farmaceutiche, University of Florence, Sesto Fiorentino, Italy;
bDipartimento di Farmacologia Preclinica e Clinica,
University of Florence, Firenze, Italy.
Keywords: Alzheimer’s disease — DM232 — DM235 — Mild cognitive impairment —
Nootropic — Sunifiram — Unifiram.
ABSTRACT
DM232 (unifiram) and DM235 (sunifiram) are potent cognition-enhancers, which are
four order of magnitude more potent than piracetam. These compounds, although not
showing affinity in binding studies for the most important central receptors or channels,
are able to prevent amnesia induced by modulation of several neurotransmission systems.
These compounds are able to increase the release of acetylcholine from rat cerebral cortex,
and, as far as unifiram is concerned, to increase the amplitude of fEPSP in rat hippocampal
slices. In vitro experiments, performed on hippocampal slices, also supported the hypothesis
of a role of the AMPA receptors for the cognition-enhancing properties of unifiram
and sunifiram.

Keywords: Alzheimer’s disease DM232 DM235 Mild cognitive impairment Nootropic Sunifiram Unifiram PDF Study

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