Limitless Nexus
Search site

exhibition Info
AMPK and PPARδ agonists mimic excercise

Type: Literature (pdf)

Submitter: [anonymous]

Category: Guides / Tutorials - Health / Medical

Exhibition Date: 2017-01-26 05:24:59 MST

Views: 380

Score: 5.00 / 5.00
(Based on 1 votes.)

Rate this exhibition

Actions

Sponsor
 
Gifts Copper Mugs Moscow Mules

Exhibition

Submitter's Comment
The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of exercise to treat metabolic diseases. Although certain natural compounds, such as reseveratrol, have endurance-enhancing activities, their exact metabolic targets remain elusive. We therefore tested the effect of pathway-specific drugs on endurance capacities of mice in a treadmill running test. We found that PPARβ/δ agonist and exercise training synergistically increase oxidative myofibers and running endurance in adult mice. Because training activates AMPK and PGC1α, we then tested whether the orally active AMPK agonist AICAR might be sufficient to overcome the exercise requirement. Unexpectedly, even in sedentary mice, 4 weeks of AICAR treatment alone induced metabolic genes and enhanced running endurance by 44%. These results demonstrate that AMPK-PPARδ pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise.

Keywords: PPARδ; AMPK; exercise running endurance skeletal muscle genetic re-programming oxidative metabolism

Most Recent User Comments
There are no comments for this exhibition yet.

Leave a comment
Please log in or create an account to post a comment.
Related sponsor

Related Literature

Other related exhibitions

Related links