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Adrafinil

Type: Image (gif)

Submitter: [anonymous]

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Exhibition Date: 2015-04-03 21:06:01 MST

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Submitter's Comment
Adrafinil (Olmifon) is a wakefulness-promoting agent (or eugeroic) used to relieve excessive sleepiness and inattention. It is also used off-label by individuals wishing to avoid fatigue, such as night workers or others who need to stay awake and alert for long periods of time.

Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil, resulting in nearly identical pharmacological effects. Unlike modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream. Effects usually are apparent within 45–60 minutes when taken orally on an empty stomach.

Adrafinil does not currently have FDA approval and is thus unregulated in the United States. It was marketed in France and elsewhere in Europe under the trade name Olmifon until September 2011 when France\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s FDA-equivalent reassessed the drug and withdrew marketing permission, citing known adverse reactions and an unsatisfactory risk to benefit ratio.

Adrafinil was discovered in the late 1970s by scientists working with the French pharmaceutical company Group Lafon. First offered in France in 1986 as an experimental treatment for narcolepsy, Lafon later developed modafinil, the primary metabolite of adrafinil. Even though the exact mechanism of action is unclear, \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\"most investigators assume that adrafinil and modafinil both serve as α1-adrenergic receptor agonists.\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\" http://en.wikipedia.org/wiki/Adrafinil

Keywords: nootriopic, racetam, modifinil, a1, agnonist, rc, smart drug, future drugs, evolving, mind expansion

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