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  Bulma in Pool - Dragon Ball Z

Submitter: [anonymous]
Type: Image (png)
Category:
submission Date: 2014-09-06 13:44:38
Last Update: 2017-07-27 23:20:25
Views: 4766
Score: (not yet rated)
 

     
  Bullet Proof Protect Gear Jin Roh The Wolf Brigade

Submitter: [anonymous]
Type: Image (gif)
Category:
submission Date: 2015-10-31 03:21:25
Views: 4546
Score: 5.00 / 5.00 (Based on 4 votes.)
 

     
  DBZ Beach Babes Ecchi - Chi-Chi, Bulma, Android 18

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-09-06 13:46:15
Views: 3641
Score: (not yet rated)
 

     
  Stephen Hawking - A Briefer History of Time

Submitter: [anonymous]
Type: Literature (pdf)
Category:
submission Date: 2014-07-24 09:06:04
Views: 3418
Score: 5.00 / 5.00 (Based on 2 votes.)
 
Table of Contents

1 - THINKING ABOUT THE UNIVERSE
2 - OUR EVOLVING PICTURE OF THE UNIVERSE
3 - THE NATURE OF A SCIENTIFIC THEORY
4 - NEWTON’S UNIVERSE
5 - RELATIVITY
6 - CURVED SPACE
7 - THE EXPANDING UNIVERSE
8 - THE BIG BANG, BLACK HOLES, AND THE EVOLUTION OF THE UNIVERSE
9 - QUANTUM GRAVITY
10 - WORMHOLES AND TIME TRAVEL
11 - THE FORCES OF NATURE AND THE UNIFICATION OF PHYSICS
12 - CONCLUSION

     
  Bulma Shower - Dragon Ball Z

Submitter: [anonymous]
Type: Image (jpg)
Category: Anime
submission Date: 2016-09-01 17:03:58
Last Update: 2017-07-27 23:22:03
Views: 2567
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Fate/Extra Saber Widescreen Wallpaper

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-08-26 15:42:56
Views: 2446
Score: (not yet rated)
 

     
  Time Space HD Wallpaper

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-07-06 09:41:59
Views: 2306
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Sleeping Zelda Nude

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-11-27 08:16:19
Views: 2250
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Horo Naked - Spice and Wolf Nude Cosplay

Submitter: [anonymous]
Type: Image (jpg)
Category: Characters
submission Date: 2016-09-03 17:30:59
Views: 2003
Score: 5.00 / 5.00 (Based on 1 votes.)
 
Holo (ホロ Horo) is a female deity and the protagonist of the light novel, manga and anime series Spice & Wolf..

     
  In Search of Antiaging Modalities: mTOR- & ROS/DNA

Submitter: [anonymous]
Type: Literature (pdf)
Category: Guides / Tutorials - Health / Medical
submission Date: 2016-06-09 15:32:35
Views: 1950
Score: (not yet rated)
 
In Search of Antiaging Modalities: Evaluation of mTOR- and ROS/DNA Damage-Signaling by Cytometry
Zbigniew Darzynkiewicz,Hong Zhao, H. Dorota Halicka, Jiangwei Li, Yong-Syu Lee, Tze-Chen Hsieh, and Joseph M. Wu
Brander Cancer Research Institute and Department of Pathology, New York Medical College,
Valhalla, New York 10595
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595

Abstract
This review presents the evidence in support of the IGF-1/mTOR/S6K1 signaling as the primary
factor contributing to aging and cellular senescence. Reviewed are also specific interactions
between mTOR/S6K1 and ROS-DNA damage signaling pathways. Outlined are critical sites
along these pathways, including autophagy, as targets for potential antiaging (gero-suppressive)
and/or chemopreventive agents. Presented are applications of flow- and laser scanning- cytometry
utilizing phospho-specific Abs, to monitor activation along these pathways in response to the
reported antiaging drugs rapamycin, metformin, berberine, resveratrol, vitamin D3, 2-
deoxyglucose, and acetylsalicylic acid. Specifically, effectiveness of these agents to attenuate the
level of constitutive mTOR signaling was tested by cytometry and confirmed by Western blotting
through measuring phosphorylation of the mTOR-downstream targets including ribosomal protein
S6. The ratiometric analysis of phosphorylated to total protein along the mTOR pathway offers a
useful parameter reporting the effects of gero-suppressive agents. In parallel, their ability to
suppress the level of constitutive DNA damage signaling induced by endogenous ROS was
measured. While the primary target of each of these agents may be different the data obtained on
several human cancer cell lines, WI-38 fibroblasts and normal lymphocytes suggest common
downstream mechanism in which the decline in mTOR/S6K1 signaling and translation rate is
coupled with a reduction of oxidative phosphorylation and ROS that leads to decreased oxidative
DNA damage. The combined assessment of constitutive γH2AX expression, mitochondrial
activity (ROS, ΔΨPm), and mTOR signaling provides an adequate gamut of cell responses to test
effectiveness of gero-suppressive agents. Described is also an in vitro model of induction of
cellular senescence by persistent replication stress, its quantitative analysis by laser scanning
cytometry, and application to detect the property of the studied agents to attenuate the induction of
senescence. Discussed is cytometric analysis of cell size and heterogeneity of size as a potential
biomarker used to asses gero-suppressive agents and longevity.

     
  Holographic Universe

Submitter: [anonymous]
Type: Image (png)
Category:
submission Date: 2014-07-30 09:05:17
Views: 1863
Score: 5.00 / 5.00 (Based on 2 votes.)
 

     
  Kanade Tachibana & yuri Nakamura Wallpaper

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-07-27 15:46:17
Last Update: 2014-07-27 15:46:33
Views: 1839
Score: (not yet rated)
 

     
  Super Saiyan God Poster Goku DBZ

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-07-06 17:48:15
Views: 1832
Score: (not yet rated)
 

     
  Love is War - Hatsune Miku Vocaloid Gun Art

Submitter: [anonymous]
Type: Image (gif)
Category:
submission Date: 2014-08-20 15:53:04
Last Update: 2014-08-20 15:53:29
Views: 1820
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Resonant Spiral - Fractal Art

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-08-31 19:05:03
Views: 1739
Score: 5.00 / 5.00 (Based on 2 votes.)
 

     
  Goth Hatsune Miku Vocaloid Wallpaper

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-08-01 02:44:17
Last Update: 2014-08-01 02:44:34
Views: 1693
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Cooler vs Frieza - DBZ Fanart

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-08-26 15:55:25
Views: 1680
Score: (not yet rated)
 

     
  VIP Secuirty Sniper

Submitter: Maro
Type: Image (jpg)
Category: People / Portraits
submission Date: 2016-03-16 20:48:15
Last Update: 2016-03-26 13:42:07
Views: 1655
Score: 5.00 / 5.00 (Based on 2 votes.)
 
You can now reserve a third Security Sniper for free for every 2 you reserve at least a month ahead of time.

http://limitlessnexus.com/vipsecurity.php

VIP Security Snipers normally require a down payment of $10,000 and $20/hr, $300/day or 10k/week, each. This means reserving 3 of them would normally require a $30k down-payment for reservation. The cost of reserving 3 VIP Security Snipers in only 20k during this offer. All reservation fees are 50% off in Tampa Bay, Palm Harbor, Oldsmar and Tarpon, Florida. 3 VIP Security Snipers can be reserved for a total of $10,000

Email NexusMadias@gmail.com or call 727 485-3516 for details/information on other security specials.

     
  Fate/Stay Night Megurine Luka Vocaloid Parody

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-08-01 14:28:05
Views: 1615
Score: (not yet rated)
 

     
  Jakuzure Nonon Nudist Beach Gear - Kill la Kill

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-07-06 10:23:27
Last Update: 2014-07-06 13:32:00
Views: 1450
Score: (not yet rated)
 

     
  Anonymous Guy Fawkes Anarchy

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2015-06-28 18:26:08
Views: 1410
Score: 5.00 / 5.00 (Based on 3 votes.)
 
anonymous-guy-fawkes-anarchy-decal_1024x1024.jpg

     
  Dragon Attacks Castle

Submitter: [anonymous]
Type: Image (jpeg)
Category:
submission Date: 2014-08-05 10:18:58
Views: 1394
Score: (not yet rated)
 

     
  Mass Effect Tali Concept

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-08-01 03:00:06
Views: 1382
Score: (not yet rated)
 
Tali\'Zorah nar Rayya

Race - Quarian
Gender - Female
Voice Actor - Ash Sroka (credited as Liz Sroka in Mass Effect and Mass Effect 2)
Appearances - Mass Effect: Homeworlds, Mass Effect, Mass Effect 2, Mass Effect 3

“The Pilgrimage proves we are willing to give of ourselves for the greater good. What does it say about me if I turn my back on this?”

Tali\'Zorah nar Rayya is a quarian and a member of Commander Shepard\'s squad. She is the daughter of Rael\'Zorah, a member of the Admiralty Board. Though young, Tali is a mechanical genius.

In 2183, she is on her Pilgrimage, the rite of passage to prove her worth and bring something of value back to her people aboard the Migrant Fleet. In 2185, having completed her Pilgrimage, Tali has been entrusted with leading an important research mission for the Admiralty Board.

     
  Ripped Muscle X The electronic roughneck stimulato

Submitter: [anonymous]
Type: Image (jpeg)
Category:
submission Date: 2016-01-22 03:57:05
Views: 1373
Score: 2.50 / 5.00 (Based on 2 votes.)
 
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  Jin-Roh: The Wolf Brigade Wallpaper

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2015-08-02 12:38:57
Views: 1334
Score: (not yet rated)
 

     
  Norwegian Flag

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2015-05-12 20:22:05
Last Update: 2015-06-05 21:44:37
Views: 1312
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Anarcho Gadsden Flag - Dont Tread on Me

Submitter: [anonymous]
Type: Image (png)
Category:
submission Date: 2015-06-16 08:31:27
Last Update: 2016-02-28 14:37:01
Views: 1296
Score: 5.00 / 5.00 (Based on 4 votes.)
 

     
  Tali without Mask

Submitter: Limitless
Type: Image (jpg)
Category:
submission Date: 2014-09-11 22:12:07
Views: 1294
Score: (not yet rated)
 

     
  Steins;Gate Wallpaper

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-09-06 17:50:48
Views: 1262
Score: (not yet rated)
 

     
  Sephiroth Advent Children

Submitter: [anonymous]
Type: Image (png)
Category:
submission Date: 2014-07-06 10:04:00
Views: 1255
Score: (not yet rated)
 

     
  3x Lunar Eclipse Wallpaper

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-05-29 02:55:02
Views: 1225
Score: 5.00 / 5.00 (Based on 2 votes.)
 
Wallpaper

     
  Spiral Fractal Flower

Submitter: [anonymous]
Type: Image (jpeg)
Category:
submission Date: 2014-08-31 18:59:56
Views: 1223
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Jin Roh Background

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2015-08-02 12:56:49
Views: 1204
Score: (not yet rated)
 

     
  VIP Security Officer

Submitter: Maro
Type: Image (jpg)
Category: People / Portraits
submission Date: 2016-03-26 13:39:00
Views: 1175
Score: 5.00 / 5.00 (Based on 2 votes.)
 
VIP Security Officers can be combined with VIP Snipers in this special offer.

http://limitlessnexus.com/vipsecurity.php

     
  Yuri Nakamura Sniper & SMG Gun Girl - Angel Beats!

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-07-19 07:11:21
Views: 1156
Score: (not yet rated)
 

     
  Helghast Shock Trooper

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-08-26 15:46:04
Views: 1137
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Sri Yantra

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2015-10-16 19:25:52
Last Update: 2015-11-01 16:47:48
Views: 1129
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  4 Forms of Frieza - DBZ

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2015-12-10 07:18:05
Views: 1116
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Pokémon Go - Type Chart for Strengths & Weaknesse

Submitter: JasonX
Type: Literature (pdf)
Category: Guides / Tutorials - Games
submission Date: 2016-09-26 08:48:38
Views: 1103
Score: 5.00 / 5.00 (Based on 3 votes.)
 
Fire-type Pokemon Strengths and Weaknesses
Effective Against: Steel, Bug, Ice, Grass
Weak Against: Rock, Water, Ground

Water-type Strengths and Weaknesses
Effective Against: Fire, Ground, Rock
Weak Against: Electric, Grass

Grass-type Pokemon Strengths and Weaknesses
Effective Against: Water, Ground Rock
Weak Against: Fire, Ice, Poison, Flying, Bug

Electric-type Pokemon Strengths and Weaknesses
Effective Against: Water, Flying
Weak Against: Ground

Normal-type Pokemon Strengths and Weaknesses
Effective Against: None
Weak Against: Fighting

Ground-type Pokemon Strengths and Weaknesses
Effective Against: Fire, Electric, Poison, Rock, Steel
Weak Against: Water, Grass, Ice

Rock-type Pokemon Strengths and Weaknesses
Effective Against: Fire, Ice, Flying, Bug
Weak Against: Water, Grass, Fighting, Ground, Steel

Fighting-type Strengths and Weaknesses
Effective Against: Normal, Ice, Rock, Dark, Steel
Weak Against: Flying, Psychic, Fairy

Ice-type Pokemon Strengths and Weaknesses
Effective Against: Grass, Ground, Flying, Dragon
Weak Against: Fire, Fighting, Rock, Steel

Poison-type Pokemon Strengths and Weaknesses
Effective Against: Grass, Fairy
Weak Against: Ground, Psychic

Psychic-type Pokemon Strengths and Weaknesses
Effective Against: Fighting, Poison
Weak Against: Bug, Ghost, Dark

Bug-type Pokemon Strengths and Weaknesses
Effective Against: Grass, Psychic, Dark
Weak Against: Fire, Flying, Rock

Flying-type Pokemon Strengths and Weaknesses
Effective Against: Grass, Fighting, Bug
Weak Against: Electric, Ice, Rock

Dragon-type Pokemon Strengths and Weaknesses
Effective Against: Dragon
Weak Against: Ice, Dragon, Fairy

Fairy-type Pokemon Strengths and Weaknesses
Effective Against: Fighting, Dragon, Dark
Weak Against: Poison, Steel

Ghost-type Pokemon Strengths and Weaknesses
Effective Against: Psychic, Ghost
Weak Against: Ghost, Dark

Dark-type Pokemon Strengths and Weaknesses
Effective Against: Psychic, Ghost
Weak Against: Fighting, Bug, Fairy

     
  Why the War on Drugs Must End

Submitter: [anonymous]
Type: Literature (pdf)
Category:
submission Date: 2014-05-30 04:38:22
Last Update: 2014-08-15 02:48:17
Views: 1065
Score: 5.00 / 5.00 (Based on 5 votes.)
 
Marijuana should be legalized. The war on drugs has been an abject failure. People are still doing drugs despite the laws. As a country, we’re spending $1 trillion each year to fight drugs. 60% of our prisons are filled with non-violent drug offenders. We’ve been battling this war for more than 40 years. Lives are still being destroyed.

Prohibition creates crime and violence. If drugs are legalized, there will still be a percentage of people who will ruin their own lives. That statistic will not change. But, they will be more likely to seek help and we will reduce the number of drug related deaths, the non-violent prison population, and the amount of felons who may struggle to get employment despite being qualified for work.

Medical marijuana is becoming acceptable among people across party lines. It’s a natural choice for pain relief.

At least one Politician running for Florida Governor is making sense, http://wyllieforgovernor.com/issues-2/marijuana/

Candidate Name: Adrian Wyllie

Governor
danielle@wyllieforgovernor.com
Wyllie For Governor
1334 Tampa Road #1
Palm Harbor, FL 34683
727-599-0001
Election year: 2014
State Campaign
- See more at: http://www.lpf.org/candidates/#sthash.NbsmcqTV.dpuf

Do your part to end the continued crimes against humanity done in the name of Drug Prohibition. Get informed and vote in local office for candidates willing to make a clear stance on legalization. Dont let the criminals who would use the government to abuse civil rights get a free pass any longer! Legalization has happened in Colorado and is spreading, most Americans agree with legalization.

Drug War Statistics

Did you know....
Amount spent annually in the U.S. on the war on drugs: More than $51,000,000,000

Number of people arrested in 2012 in the U.S. on nonviolent drug charges: 1.55 million

Number of people arrested for a marijuana law violation in 2012: 749,825

Number of those charged with marijuana law violations who were arrested for possession only: 658,231 (88 percent)

Number of Americans incarcerated in 2012 in federal, state and local prisons and jails: 2,228,400 or 1 in every 108 adults, the highest incarceration rate in the world

Proportion of people incarcerated for a drug offense in state prison that are black or Hispanic, although these groups use and sell drugs at similar rates as whites: 61 percent

Number of states that allow the medical use of marijuana: 21 + District of Columbia

Estimated annual revenue that California would raise if it taxed and regulated the sale of marijuana: $1,400,000,000

Number of people killed in Mexicos drug war since 2006: 70,000+

Number of students who have lost federal financial aid eligibility because of a drug conviction: 200,000+

Number of people in the U.S. that died from a drug overdose in 2010: 38,329

Tax revenue that drug legalization would yield annually, if currently-illegal drugs were taxed at rates comparable to those on alcohol and tobacco: $46.7 billion

The Centers for Disease Control and Prevention found that syringe access programs lower HIV incidence among people who inject drugs by: 80 percent

One-third of all AIDS cases in the U.S. have been caused by syringe sharing: 354,000 people

U.S. federal government support for syringe access programs: $0.00, thanks to a federal ban reinstated by Congress in 2011 that prohibits any federal assistance for them

http://www.drugpolicy.org/drug-war-statistics

     
  Emily Browning - Sweet Dreams (Sucker Punch Dragon

Submitter: [anonymous]
Type: Video (mp4)
Category: Film / Animation - Music
submission Date: 2016-03-14 11:54:20
Views: 1040
Score: 5.00 / 5.00 (Based on 2 votes.)
 

     
  Texas Holdem Card Rankings

Submitter: JasonX
Type: Image (png)
Category: Games
submission Date: 2016-09-26 08:50:00
Last Update: 2016-09-26 08:51:18
Views: 1028
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Jin-Roh: Angel in Vertigo Wallpaper

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2015-08-02 12:58:43
Views: 1012
Score: (not yet rated)
 

     
  Videl - DBZ Girl Fan Art

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-11-27 21:48:41
Views: 1012
Score: (not yet rated)
 

     
  Aurora-Borealis

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2015-06-05 21:43:23
Views: 1010
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Saber Alter

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-08-15 10:13:31
Views: 1004
Score: (not yet rated)
 
Saber Alter, also known as Dark Saber, is a villainess from the Fate series. She is the dark, evil version of the proud, idealistic servant Saber.

     
  Inglorious [MEP] AMV

Submitter: [anonymous]
Type: Video (mp4)
Category:
submission Date: 2014-08-04 01:51:05
Last Update: 2014-08-15 05:34:22
Views: 1003
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Genesis vs Sephiroth - FF7 Crisis Core

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2014-07-06 09:56:28
Views: 1002
Score: (not yet rated)
 

     
  Kerberos Panzer Brigade

Submitter: [anonymous]
Type: Image (jpg)
Category:
submission Date: 2015-08-02 12:57:47
Views: 983
Score: 5.00 / 5.00 (Based on 1 votes.)
 

     
  Lucy Time of Dying - Elfen Lied AMV

Submitter: [anonymous]
Type: Video (mp4)
Category:
submission Date: 2014-07-30 18:47:49
Views: 952
Score: 5.00 / 5.00 (Based on 1 votes.)
 
Anime: Elfen Lied

Song: Time Of Dying

Artist: Three Days Grace